Screening of ten wild fruits extracts from Cameroon’s flora for their anti-inflammatory and antioxidant potential

Background: Wild edible fruits are good source of phenolic compounds such as anthocyanins. Those known for their anti-inflammatory potential. They interact with many mediators the physiopathological pathway NF-kB which is at a central position in inflammatory response macrophages. This study aimed to determine and antioxidant potential ten wild aqueous extracts. Methods: The was evaluate through DPPH, ABTS OH radical scavenging activity; ferric reducing agent power total capacity assessment. Also, flavonoids, anthocyanins vitamin C content were assayed. For activity, primary macrophage culture used. Inflammatory nitric oxide (NO), alkaline phosphatase, NADPH oxidase 5-lipoxigenase activity Results: Alchornea cordifolia Pentaclethra macrophylla extracts showed greatest respectively (Antiradical (AP)=5.82 mol DPPH/mg extract AP=5.05 DPPH assay); (IC50=1.62µg/ml IC50=1.60µg/ml (IC50=32.67µg/ml IC50=70.01µg/ml assay) (EC50=54.06µg/ml EC50=17.46µg/ml power) non-significant difference reference compound. firstly it has been observed that cordifolia’s exhibits against inhibition (IC50=36.20µg/ml); phosphatase activation (EC50=0.27µg/ml) Secondly, macrophylla’s demonstrated high ability inhibit NO production (IC50=5.79µg/ml) (IC50=1.41µg/ml). Conclusion: From results obtained assessed fruit appears be sources bioactive molecules. could beneficial research new modulators management disorders.